Review of: 3gew

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3gew

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Asymmetric Unit. Macromolecule Content Total Structure Weight: This is version 1. Structural and thermodynamic characterization of pre- and postpolymerization states in the F4 fimbrial subunit FaeG Van Molle, I.

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Follow Us. To begin to study the mechanisms underlying cell identity within the neural tube we have therefore examined the development of the ventral midline cell groups.

By analyzing changes in neural cell identity and pattern within neural tube explants, we have shown that axial mesodermal cells of the notochord and prechordal mesoderm provide inductive signals that initiate the differentiation of the ventral midline and patterning of neurons within the neural plate.

Sonic hedgehog appears to mediate the induction of floor plate by notochord, but in rostral regions sonic hedgehog appears to act cooperatively with another signaling molecule to generate ventral midline cells with rostral properties.

Current experiments are directed at the molecular identification of mesoderm-derived inducing signals at different rostro-caudal levels and the characterization of the response of neuroepithelial cells to such signals.

The lab is developing methods that temporally extend genetic access to this specific population of neurons and permit identification and manipulation of dI1 specific circuits from DRG to brain, using state of the art trans-synaptic viral tracers and gene discovery.

Visualizing the synaptic connections between dI1 cells and specific functional classes of dorsal root ganglion DRG neurons, identifying central targets and the axonal routes of these neurons, and eventually manipulating their activities, will provide novel insights into the functional organization of somatosensory circuits in the developing spinal cord.

Visual System. Somatosensory System. Current Members.

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